The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.

@article{Griffin1995TheRO,
  title={The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.},
  author={Roger J. Griffin and Nicola J Curtin and David R. Newell and Bernard T Golding and Barbara W. Durkacz and Alan Hilary Calvert},
  journal={Biochimie},
  year={1995},
  volume={77 6},
  pages={408-22}
}
Poly(ADP-ribose) polymerase (PARP) plays an important role in a number of cellular processes including DNA repair. Since poly(ADP-ribosyl)ation occurs in response to radiation- or drug-induced DNA damage, inhibitors of the enzyme may enhance the antitumour activity of radiotherapy or cytotoxic drug treatment. In this review the development of PARP inhibitors is discussed, and structure-activity relationships amongst inhibitors of the enzyme are presented. Studies to date regarding the in vitro… CONTINUE READING
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