The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction.

@article{Vines1998TheRO,
  title={The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction.},
  author={A Vines and Krisna Wells and Mikhail Matrosovich and Maria Rita Castrucci and Toshihiro Ito and Yoshihiro Kawaoka},
  journal={Journal of virology},
  year={1998},
  volume={72 9},
  pages={7626-31}
}
Influenza A viruses can be isolated from a variety of animals, but their range of hosts is restricted. For example, human influenza viruses do not replicate in duck intestine, the major replication site of avian viruses in ducks. Although amino acids at positions 226 and 228 of hemagglutinin (HA) of the H3 subtype are known to be important for this host range restriction, the contributions of specific amino acids at these positions to restriction were not known. Here, we address this issue by… CONTINUE READING
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