The role of inflammatory cytokines in wound healing: accelerated healing in endotoxin-resistant mice.

@article{Bettinger1994TheRO,
  title={The role of inflammatory cytokines in wound healing: accelerated healing in endotoxin-resistant mice.},
  author={D A Bettinger and J V Pellicane and W C Tarry and Dorne R. Yager and Robert F. Diegelmann and R J Lee and I. Kelman Cohen and Eric J Demaria},
  journal={The Journal of trauma},
  year={1994},
  volume={36 6},
  pages={810-3; discussion 813-4}
}
UNLABELLED The role of cytokines in normal wound healing remains poorly defined. In vitro, tumor necrosis factor alpha (TNF-alpha) decreases collagen accumulation, perhaps by increasing collagenase activity. The current study was undertaken to test the hypothesis that cytokines impair wound healing and collagen production. Wounds in C3H/HeJ (J) mice, which are characterized by a genetic defect in macrophage production of TNF and other cytokines in response to endotoxin, were compared with… CONTINUE READING

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