The role of inflammation in the pathophysiology of CF lung disease.

  title={The role of inflammation in the pathophysiology of CF lung disease.},
  author={James F Chmiel and Melvin Berger and Michael W Konstan},
  journal={Clinical reviews in allergy & immunology},
  volume={23 1},
Cystic fibrosis (CF) lung disease is characterized by a self-perpetuating cycle of airway obstruction, chronic bacterial infection, and vigorous inflammation that results in structural damage to the airway. CF patients have a predilection for infection with a limited spectrum of distinctive bacteria that initiate a vigorous inflammatory response which is more harmful than protective. The airway epithelial cell, which normally expresses the cystic fibrosis transmembrane conductance regulator… CONTINUE READING
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