The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes.

@article{Beaulieu2010TheRO,
  title={The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes.},
  author={Lea M. Beaulieu and Jane E. Freedman},
  journal={Thrombosis research},
  year={2010},
  volume={125 3},
  pages={205-9}
}
Platelets have been extensively studied as hemostatic regulators, stopping uncontrolled flow of blood from an injured vessel and allowing for repair. However, multiple studies have shown that platelets can interact with bacterial proteins, particularly seen during sepsis and inflammation. Immune cells recognize pathogens through Toll-like Receptors (TLRs). These same receptors allow platelets to recognize bacterial proteins and regulate platelet immunity and function. This review examines the… CONTINUE READING

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