The role of inflammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension.

@article{Kherbeck2013TheRO,
  title={The role of inflammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension.},
  author={Nada Kherbeck and Mathieu C Tamby and Guillaume Bussone and Hanadi Dib and Fr{\'e}d{\'e}ric Perros and Marc Humbert and Luc Mouthon},
  journal={Clinical reviews in allergy & immunology},
  year={2013},
  volume={44 1},
  pages={31-8}
}
Pulmonary arterial hypertension is characterized by a remodeling of pulmonary arteries with endothelial cell, fibroblast, and vascular smooth muscle cell activation and proliferation. Since pulmonary arterial hypertension occurs frequently in autoimmune conditions such as systemic sclerosis, inflammation and autoimmunity have been suspected to play a critical role in both idiopathic pulmonary arterial hypertension and systemic sclerosis-associated pulmonary arterial hypertension. High levels of… CONTINUE READING