The role of inflammasome in Alzheimer's disease.

  title={The role of inflammasome in Alzheimer's disease.},
  author={Li Liu and Christina M Chan},
  journal={Ageing research reviews},
Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence… CONTINUE READING
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IPAF inflammasome is involved in interleukin-1beta

  • C. Chan
  • Reviews
  • 2014
Highly Influential
8 Excerpts

Human astrocytes

  • J. P. de Rivero Vaccari, R. W. Keane
  • 2013
Highly Influential
15 Excerpts

Alzheimer’s disease and vascular dementia. Neuropathology

  • F. Martinon, A. Mayor, J. Tschopp
  • 2009
Highly Influential
8 Excerpts

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