The role of indoleamine 2,3-dioxygenase in the anti-tumour activity of human interferon-gamma in vivo.

@article{Burke1995TheRO,
  title={The role of indoleamine 2,3-dioxygenase in the anti-tumour activity of human interferon-gamma in vivo.},
  author={Frances Burke and Richard Graham Knowles and Nick East and Frances R. Balkwill},
  journal={International journal of cancer},
  year={1995},
  volume={60 1},
  pages={115-22}
}
We have studied the relationship between L-tryptophan metabolism and the response to human IFN-gamma in 3 human ovarian cancer xenografts growing in nude mice. During IFN-gamma therapy all 3 tumours showed a profound depletion in L-tryptophan and a corresponding rise in L-kynurenine. The microenvironment surrounding the tumours was also depleted of L-tryptophan. The IFN-gamma-inducible enzyme indoleamine dioxygenase, IDO, was induced in treated tumours. While there was a variability in IDO mRNA… CONTINUE READING
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