The role of in vitro alloreactive T-cell functional tests in the selection of HLA matched and mismatched haematopoietic stem cell donors.

@article{Jeras2002TheRO,
  title={The role of in vitro alloreactive T-cell functional tests in the selection of HLA matched and mismatched haematopoietic stem cell donors.},
  author={Matja{\vz} Jeras},
  journal={Transplant immunology},
  year={2002},
  volume={10 2-3},
  pages={
          205-14
        }
}
Acute graft vs. host (GVH) disease and graft rejection are most frequently caused by undetected or disregarded genetically based disparities between the donor and recipient of bone marrow derived haematopoietic stem cells (HSC). Incompatibilities in extremely polymorphic human leukocyte antigens (HLA), and in certain cases also minor histocompatibility antigens, represent the most important driving force of such unwanted events, threatening the successful outcome of haematopoietic stem cell… CONTINUE READING