The role of immunohistochemistry in discriminating primary from secondary extramammary Paget disease.

@article{Perrotto2010TheRO,
  title={The role of immunohistochemistry in discriminating primary from secondary extramammary Paget disease.},
  author={John Perrotto and Jared J Abbott and Roger I. Ceilley and Iftikhar Ahmed},
  journal={The American Journal of dermatopathology},
  year={2010},
  volume={32 2},
  pages={137-43}
}
BACKGROUND Extramammary Paget disease (EMPD) is categorized into 2 groups: primary EMPD or EMPD secondary to underlying malignancy. Primary EMPD has a better prognosis, and the ability to distinguish between the 2 subsets has clinical relevance. Recent studies have suggested that immunostains, including cytokeratin (CK) 7, CK20, and BRST-2, distinguish between the 2 groups. We analyzed a large series of EMPD with an expanded immunohistochemical panel to assess its value in distinguishing… CONTINUE READING

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