The role of iNKT cells on the phenotypes of allergic airways in a mouse model.

@article{Lundblad2017TheRO,
  title={The role of iNKT cells on the phenotypes of allergic airways in a mouse model.},
  author={Lennart K. A. Lundblad and Nazey G{\"u}lec and Matthew E Poynter and Victoria L. DeVault and Oliver Dienz and Jonathan E Boyson and Nirav A Daphtary and Minara Aliyeva and Jennifer L. Ather and Felix Scheuplein and Robert G. Schaub},
  journal={Pulmonary pharmacology & therapeutics},
  year={2017},
  volume={45},
  pages={
          80-89
        }
}
iNKT cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of Th2 type cytokines and secretion of histamine and other mediators, respectively, which can promote airways hyperresponsiveness (AHR) to agents such as methacholine. However, a mechanistic link between iNKT cells and mast cell recruitment or activation has never been explored. Our objective was to determine whether iNKT cells are necessary for the recruitment of mast… CONTINUE READING
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