The role of hypoxia in the maintenance of hematopoietic stem cells.

@article{Cipolleschi1993TheRO,
  title={The role of hypoxia in the maintenance of hematopoietic stem cells.},
  author={M G Cipolleschi and Persio Dello Sbarba and Massimo Olivotto},
  journal={Blood},
  year={1993},
  volume={82 7},
  pages={2031-7}
}
Bone marrow cell liquid cultures were incubated at various oxygen concentrations ranging from 0% to 18% (air). The total number of cells in culture (CT) at the end of a 6-day incubation was found to be directly proportional to the oxygen concentration. As compared with air-incubated controls, cells recovered from severely hypoxic (1% oxygen) day-5 liquid cultures showed (1) the same day-7 colony-formation efficiency in semisolid culture (neutrophilic/monocytic colonies) or in spleen; (2) a… CONTINUE READING
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