The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review

@inproceedings{Herrmann2007TheRO,
  title={The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review},
  author={Markus Herrmann and Johannes Peter Schmidt and Natalia Umanskaya and Alexandra Wagner and Omid Taban‐Shomal and Thomas Widmann and Graziana Colaianni and Britt Wildemann and Wolfgang Herrmann},
  booktitle={Clinical Chemistry and Laboratory Medicine},
  year={2007},
  url={https://api.semanticscholar.org/CorpusID:7641257}
}
Existing data suggest that HHCY (and possibly B-vitamin deficiencies) adversely affects bone quality by a stimulation of bone resorption and disturbance of collagen crosslinking.

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Hyperhomocysteinemia Is Associated with Impaired Fracture Healing in Mice

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Hyperhomocysteinemia disturbs fracture healing in mice

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The effect of HHCY, which was induced by a HCY-supplemented, a methionine-supplementsed, or a B vitamin-deficient diet, on bone repair in mice was analyzed.

Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans.

The results of the present study indicate that low serum folate and vitamin B-6 concentrations, but not low serumitamin B-12 concentrations, are associated with an altered morphology of human bone.
...

Experimental hyperhomocysteinemia disturbs bone metabolism in rats

The findings demonstrate a significant modification of bone turnover in HHCY rats, which indicates a shift toward bone resorption, which might be a plausible explanation for the relation between H HCY and fracture risk.

Folate supplementation does not affect biochemical markers of bone turnover.

Short-term FA supplementation does not affect biochemical bone markers in non-osteoporotic subjects with a low folate status.

Experimental hyperhomocysteinemia reduces bone quality in rats.

Bone quality is consistently decreased in the presence of increased circulating homocysteine, providing evidence that HHCY is a causal osteoporotic factor in vivo.

Association of red blood cell 5-methyltetrahydrfoate folate with bone mineral density in postmenopausal Iranian women

It is suggested that RBC 5-MTHF is a better predictor of BMD than plasma 5-methyltetrahydrofolate when compared to a long-term marker such as BMD, and its deficiency is associated with low BMD that may contribute to the pathogenecity of osteoporosis in postmenopausal women.

The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial

B-vitamin supplementation had no consistent effects on bone turnover or BMD in osteoporotic individuals, however, the situation may be different in patients with hyperhomocysteinemia.

Methionine synthase reductase polymorphisms are associated with serum osteocalcin levels in postmenopausal women

The results suggest that the 66G/524C haplotype of the MTRR gene affect bone turn over rate, which has reduced enzyme activity, was significantly associated with serum osteocalcin levels in a gene-dose dependent manner.

Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Bone Mineral Density in Postmenopausal Japanese Women

This is the first report that suggests that the VV genotype of MTHFR is one of the genetic risk factors for low BMD.

Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial.

BACKGROUND In recent prospective studies, higher homocysteine concentrations were shown to be a risk factor for osteoporotic fractures in older persons. Supplements containing folate and vitamins
...