The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review
@inproceedings{Herrmann2007TheRO,
title={The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review},
author={Markus Herrmann and Johannes Peter Schmidt and Natalia Umanskaya and Alexandra Wagner and Omid Taban‐Shomal and Thomas Widmann and Graziana Colaianni and Britt Wildemann and Wolfgang Herrmann},
booktitle={Clinical Chemistry and Laboratory Medicine},
year={2007},
url={https://api.semanticscholar.org/CorpusID:7641257}
}Existing data suggest that HHCY (and possibly B-vitamin deficiencies) adversely affects bone quality by a stimulation of bone resorption and disturbance of collagen crosslinking.
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95 References
Experimental hyperhomocysteinemia disturbs bone metabolism in rats
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The findings demonstrate a significant modification of bone turnover in HHCY rats, which indicates a shift toward bone resorption, which might be a plausible explanation for the relation between H HCY and fracture risk.
Folate supplementation does not affect biochemical markers of bone turnover.
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Short-term FA supplementation does not affect biochemical bone markers in non-osteoporotic subjects with a low folate status.
Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans.
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Experimental hyperhomocysteinemia reduces bone quality in rats.
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Bone quality is consistently decreased in the presence of increased circulating homocysteine, providing evidence that HHCY is a causal osteoporotic factor in vivo.
Association of red blood cell 5-methyltetrahydrfoate folate with bone mineral density in postmenopausal Iranian women
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It is suggested that RBC 5-MTHF is a better predictor of BMD than plasma 5-methyltetrahydrofolate when compared to a long-term marker such as BMD, and its deficiency is associated with low BMD that may contribute to the pathogenecity of osteoporosis in postmenopausal women.
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B-vitamin supplementation had no consistent effects on bone turnover or BMD in osteoporotic individuals, however, the situation may be different in patients with hyperhomocysteinemia.
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Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial.
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BACKGROUND
In recent prospective studies, higher homocysteine concentrations were shown to be a risk factor for osteoporotic fractures in older persons. Supplements containing folate and vitamins…
