The role of human peritoneal mesothelial cells in the fibrosis and progression of gastric cancer

@inproceedings{Tsukada2012TheRO,
  title={The role of human peritoneal mesothelial cells in the fibrosis and progression of gastric cancer},
  author={Tomoya Tsukada and Sachio Fushida and Shinichi Harada and Yasumichi Yagi and Jun Kinoshita and Katsunobu Oyama and Hidehiro Tajima and Hideto Fujita and Itasu Ninomiya and Takashi Fujimura and Tetsuo Ohta},
  booktitle={International journal of oncology},
  year={2012}
}
Peritoneal dissemination is the most frequent metastatic pattern of scirrhous gastric cancer. However, despite extensive research effort, disease outcomes have not improved sufficiently. Tumor progression and metastasis result from interactions between cancer and various cells in the stroma, including endothelial cells, immune cells and fibroblasts. Fibroblasts have been particularly well studied; they are known to change into carcinoma-associated fibroblasts (CAFs) and produce transforming… CONTINUE READING

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