The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions

@article{Terry2004TheRO,
  title={The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions},
  author={George Terry and Linda Ho and Philip Londesborough and Paul A Cross and Alberto de Barros Lopes and John M Monaghan and Jack Cuzick},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={2056 - 2062}
}
The presence of high-risk human papillomavirus, loss of heterozygosity on chromosome 3p and fragile histidine triad gene expression were assessed as potential markers of cancer and CIN progression in 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions. Human papillomavirus type 16 was an indicator of vascular involvement in cancers. Loss of heterozygosity, especially in the fragile histidine triad gene intron 5, was an indicator of high-grade tumours, greater tumour… CONTINUE READING
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