The role of human papilloma virus and p16 in occult primary of the head and neck: a comprehensive review of the literature.

@article{Fotopoulos2015TheRO,
  title={The role of human papilloma virus and p16 in occult primary of the head and neck: a comprehensive review of the literature.},
  author={George Fotopoulos and Nicholas Pavlidis},
  journal={Oral oncology},
  year={2015},
  volume={51 2},
  pages={
          119-23
        }
}
Cancer of unknown primary of the head and neck is a challenging entity for the oncologist. The role of human papilloma virus/p16 in carcinogenesis and in prognosis is well established in certain HNSCC especially in that of the oropharynx. In the case of occult primary of the head and neck the role of HPV/p16 positivity is not well defined regarding prognosis and localization of the primary. An independent review of PubMed and ScienceDirect database was performed up to May 2014 using… CONTINUE READING
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