The role of human herpesvirus 8 in the pathogenesis of Kaposi's sarcoma.


Human herpesvirus 8 is a novel gamma-herpesvirus that has been linked with all clinical types of KS through both DNA and serologic studies. By electron microscopic, in situ hybridization, and in situ PCR studies, virus is found in tumor spindle cells, in normal-appearing endothelial cells within lesions, and in tumor-infiltrating leukocytes. The fact that… (More)


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