The role of hormone receptors and GTP-regulatory proteins in membrane transduction

@article{Rodbell1980TheRO,
  title={The role of hormone receptors and GTP-regulatory proteins in membrane transduction},
  author={Martin Rodbell},
  journal={Nature},
  year={1980},
  volume={284},
  pages={17-22}
}
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors. 
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