The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada.

@article{Blahna2006TheRO,
  title={The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada.},
  author={Matthew T Blahna and Christy Ann Zalewski and Jennifer Reuer and Gunnar Kahlmeter and Betsy Foxman and Carl F. Marrs},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={57 4},
  pages={666-72}
}
OBJECTIVES To describe the distribution of trimethoprim-sulfamethoxazole resistance genes and the role of horizontal gene transfer and clonal expansion in recent increases of antibiotic resistance rates among uropathogenic Escherichia coli in Europe and Canada. METHODS We identified antibiotic resistance alleles sul1, sul2, sul3 and dfr along with type 1 and type 2 integrons among 350 uropathogenic E. coli isolates from a cross-sectional study of acute, uncomplicated, community-acquired… CONTINUE READING
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