The role of histidine residues in the nonenzymic covalent attachment of glucose and ascorbic acid to protein.


Copper ions have been suggested to play a role in the non-covalent glycosylation (glycation) of proteins via transition metal-catalysed oxidations. We have further investigated "autoxidative glycosylation" by comparison of the behaviour of dog and bovine serum albumin with respect to the oxidative reactions of glucose and ascorbate. The proteins possess… (More)