Cognitive domains affected by histamine H1-antagonism in humans: A literature review
- PsychologyBrain Research Reviews
The Neglected Role of Histamine in Alzheimer’s Disease
- Biology, MedicineAmerican journal of Alzheimer's disease and other dementias
This review focuses on the role of histamine and its receptors in the treatment of AD, and it is hoped that histamine could be an effective therapeutic factor in the Treatment of AD.
The histaminergic network in the brain: basic organization and role in disease
- Psychology, BiologyNature Reviews Neuroscience
This Review explores the possible roles of brain histamine in the mechanisms underlying multiple sclerosis and experimental autoimmune encephalitis.
Histaminergic Modulation of Recognition Memory
- Biology, Psychology
The role of cortical and hypothalamic histamine‐3 receptors in the modulation of central histamine neurotransmission: an in vivo electrophysiology and microdialysis study
- Biology, MedicineThe European journal of neuroscience
It can be concluded that brain H3 receptors, and especially those expressed in the PFC, play an important role in the autoregulation of histamine neurotransmission in the rat brain.
Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep–Wake Cycle Disorder
- Biology, PsychologyFrontiers in Pharmacology
Preclinical applications of selected H3R antagonists/inverse agonists and their pharmacological effects on cognitive impairment, anxiety, depression, and sleep–wake cycle disorders are presented.
In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist
- Biology, PsychologyEuropean journal of pharmacology
Histaminergic modulation of acetylcholine-induced &ggr; oscillations in rat hippocampus
It is concluded that acetylcholine can cause histamine release from histaminergic fibers and thereby can influence attentional states by augmenting &ggr; and thereby might contribute to the previously described enhancement of working memory.
H1-histamine receptors in the amygdala are involved in emotional memory but do not mediate anxiety-related behaviors in mice submitted to EPM testing
- Biology, PsychologyBrain Research Bulletin
Histamine H3 and H4 receptors as novel drug targets
- Biology, MedicineExpert opinion on investigational drugs
This review focuses on the pharmacology of selected promising indications and the rationales for the application of H3R and H4R ligands, the newest identified member of the histamine receptor family.
SHOWING 1-10 OF 73 REFERENCES
Central histaminergic system and cognition
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
Hippocampal histamine receptors: Possible role on the mechanisms of memory in the rat, II
- Biology, PsychologyJournal of Neural Transmission
Findings confirm the previous findings about the inhibitory effect of histamine on the hippocampal retrieval mechanisms and give further support to the hypothesis that HA acts on the memory processes in the hippocampusal formation, by activation of H1-histamine receptors.
Hippocampus and learning: possible role of histamine receptors.
- Biology, PsychologyMedicina
Results suggest that histamine in hippocampus may be exerting a modulatory control on retrieval processes of memory in response to an active avoidance response.
Histamine and its receptors
- Medicine, BiologyBritish journal of pharmacology
The discovery of nonimidazole derivatives such as brain‐penetrating H3 antagonists has provided drugs that are in early‐phase clinical trials, possibly for application in obesity, and a variety of central nervous system disorders, such as memory, learning deficits and epilepsy.
Histaminergic systems of the limbic complex on learning and motivation
- Biology, PsychologyBehavioural Brain Research
Histamine H1 Receptor Antagonists Produce Increases in Extracellular Acetylcholine in Rat Frontal Cortex and Hippocampus
- BiologyJournal of neurochemistry
The data suggest that cortical and hippocampal levels of ACh can be effectively modulated by systemic treatment with histamine H1 antagonists, and may suggest that some histaminergic receptors exert an inhibitory influence over central ACh levels.
Histaminergic neurons facilitate social memory in rats
- Biology, PsychologyBrain Research
Histamine H2 Receptor Antagonists in Schizophrenia
- Medicine, Psychology
Preliminary open-label clinical trials of famotidine as an adjuvant to antipsychotics in patients with schizophrenia have been encouraging and support further exploration of H2 receptor antagonists as possible adjunctive medications for schizophrenia.