The role of hepatitis B virus-specific memory CD8 T cells in the control of viral replication.

@article{Sobao2002TheRO,
  title={The role of hepatitis B virus-specific memory CD8 T cells in the control of viral replication.},
  author={Yuji Sobao and Hiroko Tomiyama and Kazuhiro Sugi and Michiyo Tokunaga and Takamasa Ueno and Satoru Saito and Shigetoshi Fujiyama and Manabu Morimoto and Katsuaki Tanaka and Masafumi Takiguchi},
  journal={Journal of hepatology},
  year={2002},
  volume={36 1},
  pages={105-15}
}
BACKGROUND/AIMS The aim of this study is to clarify the differences of host immune responses between acute self-limited and chronic persistent hepatitis B virus (HBV) infections by quantitative and qualitative analysis of HLA-A*2402-restricted HBV-specific CD8+ T cells. METHODS HBV-specific CD8+ T cells in peripheral blood mononuclear cells (PBMCs) from patients infected with HBV were analyzed by flow cytometry using two HLA-A*2402-HBV peptide tetrameric complexes. RESULTS High numbers of… CONTINUE READING
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