The role of hepatic transporters in drug elimination.

  title={The role of hepatic transporters in drug elimination.},
  author={Christoph Funk},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={4 4},
BACKGROUND Hepatic drug transporters of the solute carrier (OATPs, OAT2, OCT1, NTCP) and ABC transporter superfamilies (MDR1, MRPs, BCRP, BSEP) can significantly modulate drug ADME routes. OBJECTIVE The currently available literature was reviewed with focus on hepatic drug transporters, related drug-drug interactions and available tools for transporter assessment and extrapolation to in vivo. CONCLUSIONS Hepatic drug transporters have gained additional importance in drug clearance by… CONTINUE READING

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