The role of hepatic lipase in lipoprotein metabolism and atherosclerosis.

  title={The role of hepatic lipase in lipoprotein metabolism and atherosclerosis.},
  author={Silvia Santamarina-Fojo and Christian D. Haudenschild and Marcelo Amar},
  journal={Current opinion in lipidology},
  volume={9 3},
In addition to its traditional role in the hydrolysis of lipoprotein triglycerides and phospholipids, recent studies have implicated hepatic lipase in other aspects of cellular lipid and/or lipoprotein metabolism and atherosclerosis. Hepatic lipase may serve as a ligand that mediates the interaction of lipoproteins to cell surface receptors and/or proteoglycans as well as modulating aortic lesion development in different animal models. Over the past several years significant advances have been… CONTINUE READING


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