The role of hepatic insulin receptors in the regulation of glucose production.

@article{Cherrington2005TheRO,
  title={The role of hepatic insulin receptors in the regulation of glucose production.},
  author={A. Cherrington},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 5},
  pages={
          1136-9
        }
}
  • A. Cherrington
  • Published 2005
  • Biology, Medicine
  • The Journal of clinical investigation
The inability of insulin to suppress hepatic glucose production (HGP) is a key defect found in type 2 diabetes. Insulin inhibits HGP through both direct and indirect means, the latter of which include inhibition of glucagon secretion, reduction in plasma nonesterified fatty acid level, decrease in the load of gluconeogenic substrates reaching the liver, and change in neural signaling to the liver. Two studies in this issue of the JCI demonstrate that selective changes in the expression of… Expand
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  • J. Girard
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2006
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