The role of hemoglobin oxygen affinity in oxygen transport at high altitude

@article{Winslow2007TheRO,
  title={The role of hemoglobin oxygen affinity in oxygen transport at high altitude},
  author={Robert M. Winslow},
  journal={Respiratory Physiology & Neurobiology},
  year={2007},
  volume={158},
  pages={121-127}
}
Hemoglobin is involved in the regulation of O(2) transport in two ways: a long-term adjustment in red cell mass is mediated by erythropoietin (EPO), a response to renal oxgyenation. Short-term, rapid-response adjustments are mediated by ventilation, cardiac output, hemoglobin oxygen affinity (P50), barriers to O(2) diffusion, and the control of local microvascular tissue perfusion. The distribution of O(2) between dissolved (PO2) and hemoglobin-bound (saturation) is the familiar oxygen… CONTINUE READING
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