The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

@article{Mercer2011TheRO,
  title={The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.},
  author={Amy E Mercer and Ian M Copple and James L. Maggs and Paul M O'neill and Brian Kevin Park},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 2},
  pages={987-96}
}
The artemisinin compounds are the frontline drugs for the treatment of drug-resistant malaria. They are selectively cytotoxic to mammalian cancer cell lines and have been implicated as neurotoxic and embryotoxic in animal studies. The endoperoxide functional group is both the pharmacophore and toxicophore, but the proposed chemical mechanisms and targets of cytotoxicity remain unclear. In this study we have used cell models and quantitative drug metabolite analysis to define the role of the… CONTINUE READING

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Angewandte Chemie-International Edition 46, 6278-6283 by gest on N ovem er 15

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