The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B(1) and B(2) bradykinin receptors.

@article{Faussner2004TheRO,
  title={The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B(1) and B(2) bradykinin receptors.},
  author={Alexander Faussner and Alexandra Bauer and Irina Kalatskaya and Steffen Sch{\"u}ssler and Cornelia Seidl and David Proud and Marianne Jochum},
  journal={The FEBS journal},
  year={2004},
  volume={272 1},
  pages={
          129-40
        }
}
Determinants for desensitization and sequestration of G protein-coupled receptors often contain serine or threonine residues located in their C-termini. The sequence context, however, in which these residues have to appear, and the receptor specificity of these motifs are largely unknown. Mutagenesis studies with the B(2) bradykinin receptor (B(2)wt), stably expressed in HEK 293 cells, identified a sequence distal to N338 (NSMGTLRTSI, including I347 but not the basally phosphorylated S348) and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS