The role of hedgehog signalling in tumorigenesis.

  title={The role of hedgehog signalling in tumorigenesis.},
  author={Carol Wicking and Edwina McGlinn},
  journal={Cancer letters},
  volume={173 1},
It has long been known from work in both Drosophila and vertebrate systems that the hedgehog signalling pathway is pivotal to embryonic development, but the past 5 years has seen an increase in our understanding of how members of this pathway are crucial to the processes of tumorigenesis. This important link was firmly established with the discovery that mutations in the gene encoding the hedgehog receptor molecule patched are responsible for both familial and sporadic forms of basal cell… CONTINUE READING
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