The role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney.

@article{ONeill2012TheRO,
  title={The role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney.},
  author={Stephen O'Neill and James Alexander Ross and Stephen J. Wigmore and Ewen M Harrison},
  journal={Expert opinion on investigational drugs},
  year={2012},
  volume={21 10},
  pages={1535-48}
}
INTRODUCTION Kidney transplantation is the gold standard treatment for end-stage renal disease. Ischemia-reperfusion injury (IRI) is an unavoidable consequence of the transplantation procedure and is responsible for delayed graft function and poorer long-term outcomes. AREAS COVERED Pharmacological induction of heat shock protein (Hsp) expression is an emerging pre-conditioning strategy aimed at reducing IRI following renal transplantation. Hsp90 inhibition up-regulates protective Hsps… CONTINUE READING
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