The role of heat shock protein 70 in vitamin D receptor function.

@article{Lutz2001TheRO,
  title={The role of heat shock protein 70 in vitamin D receptor function.},
  author={Ward H Lutz and Kenji Kohno and Rajiv Kumar},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={282 5},
  pages={1211-9}
}
We previously demonstrated that the 1alpha,25-dihydroxyvitamin D(3) receptor (VDR) interacts with the constitutive heat shock protein, hsc70 in vitro, and with DnaK (Biochem. Biophys. Res. Commun. 260, 446-452, 1999). The biological significance of VDR-heat shock protein interactions, however, is unknown. To examine the role of such interactions in eukaryotic cells, we heterologously expressed VDR and RXRalpha together with a vitamin D-responsive reporter system in Saccharomyces cerevisiae and… CONTINUE READING

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