• Corpus ID: 39083280

The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury.

@article{Thurman1998TheRO,
  title={The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury.},
  author={Ronald G. Thurman and Blair U. Bradford and Yuji Iimuro and Kathryn T. Knecht and Gavin E. Arteel and Ming Yin and Henry D. Connor and Chantal Wall and James A. Raleigh and Moritz von Frankenberg and Y Adachi and Donald T. Forman and David A. Brenner and Maria B. Kadiiska and Ronald P. Mason},
  journal={Journal of gastroenterology and hepatology},
  year={1998},
  volume={13 Suppl},
  pages={
          S39-50
        }
}
Previous research from this laboratory using a continuous enteral ethanol (EtOH) administration model demonstrated that Kupffer cells are pivotal in the development of EtOH-induced liver injury. When Kupffer cells were destroyed using gadolinium chloride (GdCl3) or the gut was sterilized with polymyxin B and neomycin, early inflammation due to EtOH was blocked. Anti-tumour necrosis factor (TNF)-alpha antibody markedly decreased EtOH-induced liver injury and increased TNF-mRNA. These findings… 
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