• Biology, Medicine
• Published in
  Archives of biochemistry and…
  1996
• DOI:10.1006/abbi.1996.0296

The role of glycosylation in synthesis and secretion of beta-amyloid precursor protein by Chinese hamster ovary cells.

@article{Phlsson1996TheRO,
  title={The role of glycosylation in synthesis and secretion of beta-amyloid precursor protein by Chinese hamster ovary cells.},
  author={Peter P{\aa}hlsson and Steven L Spitalnik},
  journal={Archives of biochemistry and biophysics},
  year={1996},
  volume={331 2},
  pages={
          177-86
        }
}

• Peter Påhlsson, Steven L Spitalnik

Alzheimer's disease is characterized by beta-amyloid deposition in the brain. This peptide is derived by proteolytic cleavage from beta-amyloid precursor protein (APP), a highly glycosylated membrane glycoprotein containing both N- and O-glycans. There are three major isoforms of APP, which are derived by alternative splicing and contain 695, 751, or 770 amino acids. Since glycosylation can affect many properties of glycoproteins, we studied the role of N- and O-glycosylation in the synthesis… CONTINUE READING

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