The role of glycosphingolipids in HIV signaling, entry and pathogenesis

@article{Viard2003TheRO,
  title={The role of glycosphingolipids in HIV signaling, entry and pathogenesis},
  author={Mathias Viard and Isabella Parolini and Satinder S. Rawat and Katia Fecchi and Massimo Sargiacomo and Adarsh Kumar Puri and Robert Blumenthal},
  journal={Glycoconjugate Journal},
  year={2003},
  volume={20},
  pages={213-222}
}
Although HIV uses CD4 and coreceptors (CCR5 and CXCR4) for productive infection of T cells, glycosphingolipids (GSL) may play ancillary roles in lymphoid and non-lymphoid cells. Interactions of the HIV Envelope Glycoprotein (Env) with GSL may help HIV in various steps of its pathogenesis. Physical-chemical aspects of the interactions between HIV Env and GSL leading to CD4-dependent entry into lymphocytes, the role of GSL in HIV transcytosis, and CD4-independent entry into non-lymphoid cells are… CONTINUE READING

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