The role of glycation cross-links in diabetic vascular stiffening

  title={The role of glycation cross-links in diabetic vascular stiffening},
  author={Trevor J. Sims and Lars Melholt Rasmussen and H R Witek Oxlund and Prof. A. J. Bailey},
Previous studies have shown that biomechanical analysis of aorta from diabetic subjects reveals a marked increase in stiffness compared to aorta from age-matched control subjects. In the present paper we have proposed that this increased stiffness can be attributed to glycation-induced inter-molecular cross-links based on a direct analysis of the two known glycation cross-links, the fluorescent pentosidine and the non-fluorescent NFC-1. There was a significant difference in the increase in… CONTINUE READING