The role of glutathione in cancer

@article{Balendiran2004TheRO,
  title={The role of glutathione in cancer},
  author={Ganesaratnam K. Balendiran and Rajesh Dabur and D Fraser},
  journal={Cell Biochemistry and Function},
  year={2004},
  volume={22}
}
Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It instils several vital roles within a cell including antioxidation, maintenance of the redox state, modulation of the immune response and detoxification of xenobiotics. With respect to cancer, glutathione metabolism is able to play both protective and pathogenic roles. It is crucial in the removal and… Expand
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This review will finally analyze whether GSH depletion may facilitate cancer cell death under in vivo conditions, and how this can be applied to cancer therapy. Expand
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The role of the GSH antioxidant system in modulating the sensitivity of Ewing's sarcoma family of tumours cells to fenretinide is heterogeneous depending on environment and cell type, likely to limit the value of targeting GSH as a therapeutic strategy to overcome hypoxia-induced drug resistance in ESFT. Expand
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The present review highlights the role of GSH and related cytoprotective effects in the susceptibility to carcinogenesis and in the sensitivity of tumors to the cytotoxic effects of anticancer agents. Expand
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Cancer constantly finds ways to survive, so we must find new ways to stop it. A major attribute of cancer cells is increased oxidative stress, occurring in the form of reactive oxygen species (ROS).… Expand
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TLDR
The current state of knowledge on the role of GSH is reviewed to underscore its relevance in translational research for future therapeutic treatment design and to modulate redox-sensitive components of signal transduction cascades. Expand
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In vitro and in vivo biomarkers of tumour redox status in response to treatments targeting the GSH and TRX pathways are assessed by comparing cytosolic and mitochondrial redox nitroxide electron paramagnetic resonance (EPR) probes, and cross-validation with redox dynamic fluorescent measurement. Expand
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New data show that the major cellular antioxidant systems, the thioredoxin (Trx) and glutathione (GSH) systems, actually promote cancer growth and HIV infection, while suppressing an effective immune response. Expand
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