The role of glutathione in cancer
@article{Balendiran2004TheRO, title={The role of glutathione in cancer}, author={G. K. Balendiran and R. Dabur and D. Fraser}, journal={Cell Biochemistry and Function}, year={2004}, volume={22} }
Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It instils several vital roles within a cell including antioxidation, maintenance of the redox state, modulation of the immune response and detoxification of xenobiotics. With respect to cancer, glutathione metabolism is able to play both protective and pathogenic roles. It is crucial in the removal and… CONTINUE READING
Topics from this paper
Paper Mentions
Blog Post
597 Citations
Multifaceted Roles of Glutathione and Glutathione-Based Systems in Carcinogenesis and Anticancer Drug Resistance.
- Biology
- 2017
- 27
Glutathione in Ovarian Cancer: A Double-Edged Sword
- Medicine
- International journal of molecular sciences
- 2018
- 33
- PDF
Glutathione in Cancer Biology and Therapy
- Biology, Medicine
- Critical reviews in clinical laboratory sciences
- 2006
- 693
Heterogeneous Role of the Glutathione Antioxidant System in Modulating the Response of ESFT to Fenretinide in Normoxia and Hypoxia
- Biology, Medicine
- PloS one
- 2011
- 4
- PDF
Role of Glutathione in Cancer Progression and Chemoresistance
- Biology, Medicine
- Oxidative medicine and cellular longevity
- 2013
- 542
- PDF
The central role of glutathione in the pathophysiology of human diseases
- Biology, Medicine
- Archives of physiology and biochemistry
- 2007
- 380
Biomarkers of tumour redox status in response to modulations of glutathione and thioredoxin antioxidant pathways
- Chemistry, Medicine
- Free radical research
- 2018
- 7
Dual targeting of the thioredoxin and glutathione systems in cancer and HIV.
- Biology, Medicine
- The Journal of clinical investigation
- 2016
- 81
- PDF
References
SHOWING 1-10 OF 93 REFERENCES
The changing faces of glutathione, a cellular protagonist.
- Chemistry, Medicine
- Biochemical pharmacology
- 2003
- 1,034
- PDF
Potential for selective modulation of glutathione in cancer chemotherapy.
- Biology, Chemistry
- Chemico-biological interactions
- 1998
- 61
Assessment of P-glycoprotein, glutathione-based detoxifying enzymes and O6-alkylguanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors.
- Medicine
- Cancer research
- 1991
- 93
- PDF
Glutathione conjugation as a mechanism for the transport of reactive metabolites.
- Chemistry, Medicine
- Advances in pharmacology
- 1994
- 28
Glutathione conjugate mediated toxicities.
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1990
- 209