The role of glutathione in cancer

@article{Balendiran2004TheRO,
  title={The role of glutathione in cancer},
  author={Ganesaratnam Balendiran and Rajesh Dabur and D Fraser},
  journal={Cell Biochemistry and Function},
  year={2004},
  volume={22}
}
Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It instils several vital roles within a cell including antioxidation, maintenance of the redox state, modulation of the immune response and detoxification of xenobiotics. With respect to cancer, glutathione metabolism is able to play both protective and pathogenic roles. It is crucial in the removal and… 
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732 Citations
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732 Citations

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The ability to inhibit TrxR1 function with small molecule drug candidates, the role such inhibition has on modulating ROS levels, and whether such inhibition is sufficient to elicit anticancer therapeutic effects are examined.

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The current state of knowledge on the role of GSH is reviewed to underscore its relevance in translational research for future therapeutic treatment design and to modulate redox-sensitive components of signal transduction cascades.

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New data show that the major cellular antioxidant systems, the thioredoxin (Trx) and glutathione (GSH) systems, actually promote cancer growth and HIV infection, while suppressing an effective immune response.

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...

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