The role of glutathione in cadmium ion detoxification: coordination modes and binding properties--a density functional study.

@article{Belcastro2009TheRO,
  title={The role of glutathione in cadmium ion detoxification: coordination modes and binding properties--a density functional study.},
  author={M. Belcastro and T. Marino and N. Russo and M. Toscano},
  journal={Journal of inorganic biochemistry},
  year={2009},
  volume={103 1},
  pages={
          50-7
        }
}
  • M. Belcastro, T. Marino, +1 author M. Toscano
  • Published 2009
  • Chemistry, Medicine
  • Journal of inorganic biochemistry
  • In this investigation the reduced form of glutathione molecule (GSH) was considered as a model in the coordination chemistry of Cd(2+) and group thiol-containing peptides. Three different forms of GSH, corresponding to the prevalent ones in gas-phase and in aqueous solution, were taken into account in the metallation process. The obtained complexes were characterized at the density functional B3LYP level with the purpose to give better insight in the chelation mechanism of GSH with heavy metal… CONTINUE READING
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    References

    SHOWING 1-10 OF 117 REFERENCES
    Coordination chemistry of glutathione.
    • 78
    Spectral studies on copper(II) complexes of biologically active glutathione.
    • 34
    Ca, Cd, Zn, and their ions interacting with Cytosine: a theoretical study.
    • 17
    Cobalt(II) complexes of biologically active glutathione: spectroscopic and molecular modeling studies.
    • 27
    1H,13C-NMR and X-ray absorption studies of copper(I) glutathione complexes.
    • 103