The role of glutaminase in the small intestine.

  title={The role of glutaminase in the small intestine.},
  author={Rosalie D McCauley and S E Kong and Kathryn A. Heel and John Kelseyy Doug Whitingz David Wagnerx Chris Hall},
  journal={The international journal of biochemistry & cell biology},
  volume={31 3-4},
Glutaminase is the enzyme which hydrolyses glutamine, the main respiratory fuel of the intestine, to yield glutamate and ammonia. Glutaminase has a central role in intestinal metabolism: the products of the reaction catalyzed by glutaminase can be transaminated, catabolized to yield energy or used for the biosynthesis of pyrimidine nucleotides. Experimental treatments which deprive the intestine of glutamine induce intestinal atrophy. In this review, attention is paid to the role of glutaminase… CONTINUE READING