The role of glucose 6‐phosphate in the control of glycogen synthase

@article{ViijlarPalas1997TheRO,
  title={The role of glucose 6‐phosphate in the control of glycogen synthase},
  author={Carlos Viijlar‐Palas{\'i} and Joan J. Guinovart},
  journal={The FASEB Journal},
  year={1997},
  volume={11},
  pages={544 - 558}
}
Elevated blood glucose concentrations result in increased intracellular levels of glucose 6‐phosphate in liver, skeletal muscle, and adipose tissue. In liver, blood glucose concentrations are the main factor in control of the synthesis of glycogen; insulin has only a potentiating effect. In skeletal muscle and adipocytes, glucose alone has little effect on the activity of glycogen synthase, the limiting enzyme in glycogen synthesis. However, insulin released as a result of elevated blood… 
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References

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TLDR
No difference was found between healthy and diabetic rats in the capacity of glycogen synthase to translocate to pellets in response to an increase in glucose 6-phosphate, but in diabetic hepatocytes, this sugar was able to activate the enzyme found in the fractions that could be pelleted.
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TLDR
It is indicated that glucose 6-phosphate plays a role in the translocation of glycogen synthase in rat hepatocytes and Microcystin, which blocks the activation of glucose by glucose, but not the accumulation of glucose6-ph phosphate, did not affect the translocated of the enzyme.
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TLDR
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TLDR
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TLDR
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