Corpus ID: 2347260

The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease.

@article{Kelly1998TheRO,
  title={The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease.},
  author={Gregory S. Kelly},
  journal={Alternative medicine review : a journal of clinical therapeutic},
  year={1998},
  volume={3 1},
  pages={
          27-39
        }
}
  • G. Kelly
  • Published 1998
  • Chemistry, Medicine
  • Alternative medicine review : a journal of clinical therapeutic
Successful treatment of osteoarthritis must effectively control pain, and should slow down or reverse progression of the disease. Biochemical and pharmacological data combined with animal and human studies demonstrate glucosamine sulfate is capable of satisfying these criteria. Glucosamine sulfate's primary biological role in halting or reversing joint degeneration appears to be directly due to its ability to act as an essential substrate for, and to stimulate the biosynthesis of, the… Expand
The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals.
TLDR
The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals is reviewed to provide veterinary practitioners with up-to-date information regarding the mechanism of action, pharmacokinetics, clinical efficacy, and safety. Expand
GLUCOSAMINE SULFATE: A STRUCTURE MODIFYING DRUG FOR OSTEOARTHRITIS
TLDR
OA clinical trials have shown that long-term use of GS (1,500 mg/day) can delay the disease progression and control OA signs and symptoms and GS is well tolerated and no severe adverse effects have been observed in GS treated patients. Expand
Articular cartilage proteoglycan biosynthesis and sulfation
Glucosamine (GlcN) and glucosamine sulfate (GS) have been used to treat the patients with osteoarthritis (OA) as a disease-modifying agent. Previous in vitro studies have focused on the effects ofExpand
NUTRACEUTICAL FORMULATIONS CONTAINING GLUCOSAMINE AND CHONDROITIN SULPHATE IN THE TREATMENT OF OSTEOARTHRITIS: EMPHASIS ON CLINICAL EFFICACY AND FORMULATION CHALLENGES
TLDR
The purpose of this review article is to report the current evidence for the use of glucosamine and chondroitin sulphate in the treatment of knee OA with emphasis on their indications for clinical use, effectiveness and safety, and highlights the role of some advanced formulation technologies in optimizing the delivery of those drugs. Expand
Glucosamine and Chondroitin for Osteoarthritis
  • E. Huskisson
  • Medicine
  • The Journal of international medical research
  • 2008
TLDR
Glucosamine and chondroitin, classed as over-the-counter supplements or nutraceuticals, are regularly self-administered by patients with OA and the evidence that supports their use either alone or in combination for pain relief and as disease-modifying agents in OA is discussed. Expand
EVALUATION OF TOLERABILITY AND EFFICACY OF GLUCOSAMINE WITH CHONDROITIN IN THE TREATMENT OF KNEE OSTEOARTHRITIS - A DOUBLE BLIND MULTICENTRE RANDOMIZED PROSPECTIVE COMPARATIVE STUDY
TLDR
The results of this study suggest that GlcN2 and ChoN3 can relieve pain, improving functional ability and joint mobility so as to enhance the quality of life for osteoarthritis patients. Expand
THE STATUS OF GLUCOSAMINE FOR THE RELIEF OF OSTEOARTHRITIS
Glucosamine is an amino sugar molecule used by many people to relieve the pain, discomfort, and progression of osteoarthritis. The benefit of using glucosamine to treat osteoarthritis has beenExpand
The lack of effect of glucosamine sulphate on aggrecan mRNA expression and (35)S-sulphate incorporation in bovine primary chondrocytes.
TLDR
Northern blot assay showed that neither hexosamines nor glucosamine sulphate salt stimulated aggrecan and HAS-2 mRNA expression, and Glycosaminoglycan synthesis remained at a control level in the treated cultures, with the exception of mannosamine which inhibited (35)S-sulphate incorporation in low-glucose DMEM treatment. Expand
Effects of Chondroitin and Glucosamine Sulfate in a Dietary Bar Formulation on Inflammation, Interleukin-1β, Matrix Metalloprotease-9, and Cartilage Damage in Arthritis
TLDR
Combination CS plus GS treatment in a dietary bar formulation ameliorates clinical, inflammatory, and histologic parameters of adjuvant-induced arthritis and reduction of arthritic disease is associated with a reduction of IL-1 β and MMP-9 synthesis. Expand
The Role of Glucoseamine Sulfate on Osteoarthritis: An update
TLDR
It has been suggested that glucose amine could be beneficial in promoting the regeneration of damaged cartilage from injury and may be helpful to compensate the normal metabolic turnover of the extracellular matrix and to prevent the degradation of cartilage by stimulating the healing process when it is damaged. Expand
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