The role of glial cells in Parkinson's disease.

  title={The role of glial cells in Parkinson's disease.},
  author={Miquel Vila and Vernice R. Jackson-Lewis and Christelle Gu{\'e}gan and Du Chu Wu and Peter Teismann and D K Choi and Kim Tieu and Serge E. Przedborski},
  journal={Current opinion in neurology},
  volume={14 4},
Parkinson's disease is a common neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta. The loss of these neurons is associated with a glial response composed mainly of activated microglial cells and, to a lesser extent, of reactive astrocytes. This glial response may be the source of trophic factors and can protect against reactive oxygen species and glutamate. Aside from these beneficial effects, the glial response… CONTINUE READING
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