The role of glia in late-life depression.

  title={The role of glia in late-life depression.},
  author={Matt Paradise and Sharon L Naismith and Louisa Margaret Norrie and Manuel Gr{\"a}ber and Ian B. Hickie},
  journal={International psychogeriatrics},
  volume={24 12},
Late-life depression (LLD) has a complex and multifactoral etiology. There is growing interest in elucidating how glia, acting alone or as part of a glial-neuronal network, may contribute to the pathophysiology of depression. In this paper, we explore results from neuroimaging studies showing gray-matter volume loss in key frontal and subcortical structures implicated in LLD, and present the few histological studies that have examined neuronal and glial densities in these regions. Compared to… CONTINUE READING
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