The role of genetic factors in autoimmune disease: implications for environmental research.

@article{Cooper1999TheRO,
  title={The role of genetic factors in autoimmune disease: implications for environmental research.},
  author={Glinda S. Cooper and Frederick W Miller and Janardan P Pandey},
  journal={Environmental Health Perspectives},
  year={1999},
  volume={107},
  pages={693 - 700}
}
Studies in both humans and in animal models of specific disorders suggest that polymorphisms of multiple genes are involved in conferring either a predisposition to or protection from autoimmune diseases. Genes encoding polymorphic proteins that regulate immune responses or the rates and extent of metabolism of certain chemical structures have been the focus of much of the research regarding genetic susceptibility. We examine the type and strength of evidence concerning genetic factors and… CONTINUE READING

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