The role of genes and environment in the etiology of PCOS

@article{DiamantiKandarakis2007TheRO,
  title={The role of genes and environment in the etiology of PCOS},
  author={Evanthia Diamanti-Kandarakis and Helen A Kandarakis and Richard S. Legro},
  journal={Endocrine},
  year={2007},
  volume={30},
  pages={19-26}
}
Both genes and the environment contribute to PCOS. Obesity, exacerbated by poor dietary choices and physical inactivity, worsens PCOS in susceptible individuals. The role of other environmental modifiers such as infectious agents or toxins are speculative. Phenotype confusion has characterized genetic studies of PCOS. Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, the follistatin gene, and a region near the insulin receptor, the evidence supporting… 

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