The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis.

@article{Bove2014TheRO,
  title={The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis.},
  author={Riley M Bove and Tanuja Chitnis},
  journal={Multiple sclerosis},
  year={2014},
  volume={20 5},
  pages={
          520-6
        }
}
Intriguing sex differences both in multiple sclerosis (MS) susceptibility and its disease course may offer important insights into MS disease pathophysiology, prevention and treatment. In this review, we first summarize the key sex-related differences in MS risk, heritability and disease progression. One promising hypothesis we explore is whether sexually-dimorphic responsiveness to cultural and environmental changes may explain the observation of an increasing female:male sex ratio in MS. We… CONTINUE READING
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