The role of gap junctions in seizures

  title={The role of gap junctions in seizures},
  author={Peter L. Carlen and Frances K. Skinner and L Zhang and Christian C. Naus and Jos{\'e} Luis P{\'e}rez Velazquez},
  journal={Brain Research Reviews},
Electrotonic synaptic communication between neurons via gap junctions (gjs) is increasingly recognized as an important synchronizing mechanism in the brain. At the same time, the biology of central nervous system (CNS) gjs is being unravelled. The pathogenesis of the abnormal neuronal synchrony underlying seizures, formerly thought to be based mainly on chemical synaptic transmission, now includes a role for gap junctional communication. This concept has been strengthened by evidence from… CONTINUE READING


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