The role of gamma-tubulin in mitotic spindle formation and cell cycle progression in Aspergillus nidulans.

@article{Martn1997TheRO,
  title={The role of gamma-tubulin in mitotic spindle formation and cell cycle progression in Aspergillus nidulans.},
  author={Mar{\'i}a Angela Mart{\'i}n and Stephen A Osmani and Berl R Oakley},
  journal={Journal of cell science},
  year={1997},
  volume={110 ( Pt 5)},
  pages={623-33}
}
gamma-Tubulin has been hypothesized to be essential for the nucleation of the assembly of mitotic spindle microtubules, but some recent results suggest that this may not be the case. To clarify the role of gamma-tubulin in microtubule assembly and cell-cycle progression, we have developed a novel variation of the gene disruption/heterokaryon rescue technique of Aspergillus nidulans. We have used temperature-sensitive cell-cycle mutations to synchronize germlings carrying a gamma-tubulin… CONTINUE READING