The role of gamma interferon in innate immunity in the zebrafish embryo.

@article{Sieger2009TheRO,
  title={The role of gamma interferon in innate immunity in the zebrafish embryo.},
  author={Dirk Sieger and Cornelia Stein and David Neifer and Astrid Marijke van der Sar and Maria Leptin},
  journal={Disease models & mechanisms},
  year={2009},
  volume={2 11-12},
  pages={571-81}
}
The zebrafish genome contains ten genes that encode class II cytokine-like peptides, of which the two that are related most closely to mammalian interferon gamma (IFN-gamma) were named IFN-gamma1 and IFN-gamma2. Although the zebrafish has become a popular model system to study immune mechanisms, and although interferons are central regulators of immunity, which zebrafish cytokines correspond functionally to mammalian IFN-gamma has not been established. We used zebrafish embryos to assay the… CONTINUE READING
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