The role of galectin-3 in promotion of the inflammatory response.

  title={The role of galectin-3 in promotion of the inflammatory response.},
  author={Fu-tong Liu and Daniel Kaiyuan Hsu},
  journal={Drug news & perspectives},
  volume={20 7},
Galectin-3 is a member of a family of beta-galactoside-binding animal lectins and is distinct from other members by the presence of tandem repeats in its N-terminal region. Like other members, galectin-3 lacks a classical signal sequence, but the protein is secreted by a nonclassical secretary pathway and can function extracellularly in an autocrine or paracrine fashion. Galectin-3 is able to oligomerize and participate in multivalent interactions with cell surface and extracellular matrix… CONTINUE READING
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