The role of galectin-3 and galectin-3-binding protein in venous thrombosis.

  title={The role of galectin-3 and galectin-3-binding protein in venous thrombosis.},
  author={Elise P DeRoo and Shirley K. Wrobleski and Evelyn M Shea and Ramsey K Al-Khalil and Angela Eileen Hawley and Peter K. Henke and Daniel Durant Myers and Thomas W. Wakefield and Jose Antonio Diaz},
  volume={125 11},
Galectin-3-binding protein (gal3bp) and its receptor/ligand, galectin-3 (gal3), are secreted proteins that initiate signaling cascades in several diseases, and recent human proteomic data suggest they may play a role in venous thrombosis (VT). We hypothesized that gal3bp and gal3 may promote VT. Using a mouse stasis model of VT, we found that gal3bp and gal3 were localized on vein wall, red blood cells, platelets, and microparticles, whereas leukocytes expressed gal3 only. Gal3 was dramatically… CONTINUE READING


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